ACTA VETERINARIA ET ZOOTECHNICA SINICA ›› 2017, Vol. 48 ›› Issue (6): 971-978.doi: 10.11843/j.issn.0366-6964.2017.06.001

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Research Progress on Reproduction Regulation of SOX9 Gene in Male Mammals

LI Tao-tao1,2, MA You-ji1,2*, ZHAO Xing-xu3   

  1. 1. College of Animal Science and Technology, Gansu Agricultural University, Lanzhou 730070, China;
    2. Sheep Breeding Biotechnology Engineering Laboratory of Gansu Province, Minqin 733300, China;
    3. College of Veterinary Medicine, Gansu Agricultural University, Lanzhou 730070, China
  • Received:2016-12-02 Online:2017-06-23 Published:2017-06-23

Abstract:

Sex determining region Y-box 9 (SOX9),an important member of the SRY-type HMG box (SOX) gene family, is another sex determination gene discovered after Sex-determining region of Y chromosome. Recent studies have shown that SOX9 gene plays an important role in the regulation of mammalian reproductive activity, and is closely related to sex differentiation and spermatogenesis. Some research progress in the structural characteristics of SOX9 gene and its function in regulating reproductive activity of mammals during the embryonic and postnatal development were reviewed, aiming to provide reference for further researching its molecular mechanisms in regulating reproductive activities alone or with other gene.

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